Examining the rare disease assumption used to justify HWE testing with control samples

Examining the rare disease assumption used to justify HWE testing with control samples

Many statistical methods for analyzing genetic data, such as those used in genome-wide association studies, assume Hardy-Weinberg Equilibrium (HWE). Therefore, to use such methods, one must check whether the HWE assumption is valid. For a case-control study, researchers have recognized that Hardy We...

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Bibliographic Details
Main Authors: Virginia L. Ma, Shili Lin
Format: Article
Language:English
Published: AIMS Press 2020-01-01
Series:Mathematical Biosciences and Engineering
Subjects:
hardy-weinberg equilibrium
case-control study
rare disease assumption
genome-wide association studies
1000 genomes project
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2020004?viewType=HTML

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https://www.aimspress.com/article/doi/10.3934/mbe.2020004?viewType=HTML

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