Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine

Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine

A <sup>1</sup>H-NMR-based metabolomic study was performed on MCF-7 cell lines treated with a novel nicotinamide derivative (DT-8) in comparison with two drugs characterized by a well-established mechanism of action, namely the DNA-metalating drug cisplatin (cis-diamminedichloridoplatinum...

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Bibliographic Details
Main Authors: Laura Del Coco, Maria Majellaro, Angelina Boccarelli, Saverio Cellamare, Cosimo Damiano Altomare, Francesco Paolo Fanizzi
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Molecules
Subjects:
biaryl nicotinamide
breast cancer
antiproliferative activity
metabolomics
NMR spectroscopy
MVA
Online Access:https://www.mdpi.com/1420-3049/25/15/3502

Internet

https://www.mdpi.com/1420-3049/25/15/3502

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