Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality

Abstract Substance dependence diagnoses (SDs) are important risk factors for suicidality. We investigated the associations of multiple SDs with different suicidality outcomes, testing how genetic background moderates these associations. The Yale-Penn cohort (N = 15,557) was recruited to investigate...

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Bibliographic Details
Main Authors: Renato Polimanti, Daniel F. Levey, Gita A. Pathak, Frank R. Wendt, Yaira Z. Nunez, Robert J. Ursano, Ronald C. Kessler, Henry R. Kranzler, Murray B. Stein, Joel Gelernter
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-020-01153-1