Reflection and observation: cell-based screening failing to detect HBV in HUMSCs derived from HBV-infected mothers underscores the importance of more stringent donor eligibility to reduce risk of transmission of infectious diseases for stem cell-based medical products

Reflection and observation: cell-based screening failing to detect HBV in HUMSCs derived from HBV-infected mothers underscores the importance of more stringent donor eligibility to reduce risk of transmission of infectious diseases for stem cell-based medical products

Abstract Background In cell-based therapy, the transmission of communicable diseases imposes a substantial threat to recipients. In this study, we investigated whether cell-based screening could detect hepatitis B virus (HBV) in human umbilical cord-derived mesenchymal stem cells (HUMSCs) isolated f...

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Bibliographic Details
Main Authors: Wei Liu, Yuanyuan Xie, Tianyun Gao, Feifei Huang, Liudi Wang, Lijun Ding, Wenqing Wang, Shuo Liu, Jianwu Dai, Bin Wang
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Stem Cell Research & Therapy
Subjects:
Human umbilical cord mesenchymal stem cells
Cell-based therapy
Clinical screening assay
Hepatitis B virus
Serological test
Droplet digital PCR
Online Access:http://link.springer.com/article/10.1186/s13287-018-0920-3

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http://link.springer.com/article/10.1186/s13287-018-0920-3

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