A roadmap to using randomization in clinical trials

A roadmap to using randomization in clinical trials

Abstract Background Randomization is the foundation of any clinical trial involving treatment comparison. It helps mitigate selection bias, promotes similarity of treatment groups with respect to important known and unknown confounders, and contributes to the validity of statistical tests. Various r...

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Bibliographic Details
Main Authors: Vance W. Berger, Louis Joseph Bour, Kerstine Carter, Jonathan J. Chipman, Colin C. Everett, Nicole Heussen, Catherine Hewitt, Ralf-Dieter Hilgers, Yuqun Abigail Luo, Jone Renteria, Yevgen Ryeznik, Oleksandr Sverdlov, Diane Uschner, for the Randomization Innovative Design Scientific Working Group
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Medical Research Methodology
Subjects:
Balance
Randomization-based test
Restricted randomization design
Validity
Online Access:https://doi.org/10.1186/s12874-021-01303-z

Internet

https://doi.org/10.1186/s12874-021-01303-z

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