The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus

The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus

Staphylococcus aureus produces bacillithiol (BSH) as major low molecular weight (LMW) thiol which functions in thiol-protection and redox-regulation by protein S-bacillithiolation under hypochlorite stress. The aldehyde dehydrogenase AldA was identified as S-bacillithiolated at its active site Cys27...

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Bibliographic Details
Main Authors: Marcel Imber, Vu Van Loi, Sylvia Reznikov, Verena Nadin Fritsch, Agnieszka J. Pietrzyk-Brzezinska, Janek Prehn, Chris Hamilton, Markus C. Wahl, Agnieszka K. Bronowska, Haike Antelmann
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Redox Biology
Subjects:
Staphylococcus aureus
AldA
Bacillithiol
Hypochlorite stress
MD simulations
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231717308765

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http://www.sciencedirect.com/science/article/pii/S2213231717308765

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