The Molecular Evolution of Type 2 Vaccine-Derived Polioviruses in Individuals with Primary Immunodeficiency Diseases

The oral poliovirus vaccine (OPV), which prevents person-to-person transmission of poliovirus by inducing robust intestinal immunity, has been a crucial tool for global polio eradication. However, polio outbreaks, mainly caused by type 2 circulating vaccine-derived poliovirus (cVDPV2), are increasin...

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Bibliographic Details
Main Authors: Kouichi Kitamura, Hiroyuki Shimizu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/13/7/1407