Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease

Coronavirus main protease is essential for viral polyprotein processing and maturation. Here Fu et al. report efficient inhibition of SARS-CoV-2 replication using two inhibitors - Boceprevir and GC376 - targeting the active site of the main viral protease.

Bibliographic Details
Main Authors: Lifeng Fu, Fei Ye, Yong Feng, Feng Yu, Qisheng Wang, Yan Wu, Cheng Zhao, Huan Sun, Baoying Huang, Peihua Niu, Hao Song, Yi Shi, Xuebing Li, Wenjie Tan, Jianxun Qi, George Fu Gao
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18233-x

Internet

https://doi.org/10.1038/s41467-020-18233-x

Similar Items