Potentiating tumor immunity using aptamer-targeted RNAi to render CD8+ T cells resistant to TGFβ inhibition

Potentiating tumor immunity using aptamer-targeted RNAi to render CD8+ T cells resistant to TGFβ inhibition

TGFβ secreted by tumor cells and/or tumor infiltrating stromal cells is a key mediator of tumor growth and immune suppression at the tumor site. Nonetheless, clinical trials in cancer patients targeting the TGFβ pathway exhibited at best a modest therapeutic benefit. A likely reason, a common limita...

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Bibliographic Details
Main Authors: Yvonne Puplampu-Dove, Tal Gefen, Anugraha Rajagopalan, Darija Muheramagic, Brett Schrand, Eli Gilboa
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
aptamers
cancer immunotherapy
preclinical mouse models
sirna
tumor targeting
tgfβ
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1349588

Internet

http://dx.doi.org/10.1080/2162402X.2017.1349588

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