Attenuation of Pb-induced Aβ generation and autophagic dysfunction via activation of SIRT1: Neuroprotective properties of resveratrol

Attenuation of Pb-induced Aβ generation and autophagic dysfunction via activation of SIRT1: Neuroprotective properties of resveratrol

This study examined the neuroprotective properties of resveratrol (Res) and its target sirtuin1 (SIRT1) against lead (Pb)-mediated toxicity and discovered that both resveratrol treatment and SIRT1 overexpression restored blocked autophagic flux as well as reduced β-amyloid (Aβ) contents. Four-week-o...

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Bibliographic Details
Main Authors: Lin Bai, Rundong Liu, Ruike Wang, Yongjuan Xin, Zuntao Wu, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huang
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Resveratrol
SIRT1
Lead
Autophagy
Aβ
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321006230

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http://www.sciencedirect.com/science/article/pii/S0147651321006230

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