Weight loss reversed obesity-induced HGF/c-Met pathway and basal-like breast cancer progression

Weight loss reversed obesity-induced HGF/c-Met pathway and basal-like breast cancer progression

Epidemiologic studies demonstrate that obesity is associated with an aggressive subtype of breast cancer called basal-like breast cancer (BBC). Using the C3(1)-TAg murine model of BBC, we previously demonstrated that mice displayed an early onset of tumors when fed obesogenic diets in the adult wind...

Full description

Bibliographic Details
Main Authors: Sneha eSundaram, Trinh L Le, Luma eEssaid, Alex J Freemerman, Megan J Huang, Joseph A Galanko, Kirk K McNaughton, Katharine M Bendt, David B Darr, Melissa A Troester, Liza eMakowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Oncology
Subjects:
Adiponectin
Leptin
BMI
microenvironment
high fat diet
Triple negative
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00175/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00175/full

Similar Items