Heterogeneous response of endothelial cells to insulin-like growth factor 1 treatment is explained by spatially clustered sub-populations

A common strategy to measure the efficacy of drug treatment is the in vitro comparison of ensemble readouts with and without treatment, such as proliferation and cell death. A fundamental assumption underlying this approach is that there exists minimal cell-to-cell variability in the response to a d...

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Bibliographic Details
Main Authors: Christina Kim, Gregory J. Seedorf, Steven H. Abman, Douglas P. Shepherd
Format: Article
Language:English
Published: The Company of Biologists 2019-11-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/8/11/bio045906