Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice

Expression of Chitotriosidase in Macrophages Modulates Atherosclerotic Plaque Formation in Hyperlipidemic Mice

ObjectiveTo determine whether overexpression of the chitin degrading enzyme, chitotriosidase (CHIT1), modulates macrophage function and ameliorates atherosclerosis.Approach and ResultsUsing a mouse model that conditionally overexpresses CHIT1 in macrophages (CHIT1-Tg) crossbred with the Ldlr–/– mous...

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Bibliographic Details
Main Authors: Jonathan Yap, Sara McCurdy, Martin Alcala, Jason Irei, Jan Garo, Whitney Regan, Bog-Hieu Lee, Shiro Kitamoto, William A. Boisvert
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Physiology
Subjects:
atherosclerosis
macrophage
chitotriosidase
hyaluronic acid
collagen
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00714/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00714/full

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