Chitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis

Chitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis

Abstract Background Chitinase 3 like 1 protein (Chi3L1) is expressed in several cancers, and a few evidences suggest that the secreted Chi3L1 contributes to tumor development. However, the molecular mechanisms of intracellular Chi3L1 are unknown in the lung tumor development. Methods: In the present...

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Bibliographic Details
Main Authors: Kyung-Ran Park, Hyung-Mun Yun, Kyeongwon Yoo, Young Wan Ham, Sang Bae Han, Jin Tae Hong
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell Communication and Signaling
Subjects:
Intracellular Chi3L1
p53
Knockout mice
Lung cancer
Tumor development
Online Access:http://link.springer.com/article/10.1186/s12964-019-0503-7

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http://link.springer.com/article/10.1186/s12964-019-0503-7

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