Aspergillus fumigatus Infection in Humans With STAT3-Deficiency Is Associated With Defective Interferon-Gamma and Th17 Responses

Aspergillus fumigatus Infection in Humans With STAT3-Deficiency Is Associated With Defective Interferon-Gamma and Th17 Responses

In humans, loss-of-function mutation in the Signal Transducer and Activator of Transcription 3 (STAT3) gene is frequently associated with susceptibility to bacterial as well as fungal infections including aspergillosis, although its pathogenesis remains largely unknown. In the present study, we inve...

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Bibliographic Details
Main Authors: François Danion, Vishukumar Aimanianda, Jagadeesh Bayry, Amélie Duréault, Sarah Sze Wah Wong, Marie-Elisabeth Bougnoux, Colas Tcherakian, Marie-Alexandra Alyanakian, Hélène Guegan, Anne Puel, Capucine Picard, Olivier Lortholary, Fanny Lanternier, Jean-Paul Latgé
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
signal transducer and activator of transcription 3 (STAT3)
loss-of-function mutation
aspergillosis
innate/adaptive immunity
autosomal dominant hyper-IgE syndrome (AD-HIES)
Aspergillus
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00038/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00038/full

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