Oligomerization interface of RAGE receptor revealed by MS-monitored hydrogen deuterium exchange.

Activation of the receptor for advanced glycation end products (RAGE) leads to a chronic proinflammatory signal, affecting patients with a variety of diseases. Potentially beneficial modification of RAGE activity requires understanding the signal transduction mechanism at the molecular level. The li...

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Bibliographic Details
Main Authors: Ewa Sitkiewicz, Krzysztof Tarnowski, Jarosław Poznański, Magdalena Kulma, Michal Dadlez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3788119?pdf=render