The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens

Abstract A persistent goal of vaccine development is the enhancement of the immunogenicity of antigens while maintaining safety. One strategy involves alteration of the presentation of the antigen by combining antigens with a multimeric scaffold. Multi-antigen vaccines are under development, and the...

Full description

Bibliographic Details
Main Authors: Pauline M. van Diemen, Darren B. Leneghan, Iona J. Brian, Kazutoyo Miura, Carole A. Long, Anita Milicic, Sumi Biswas, Christine S. Rollier, David H. Wyllie
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01421-z