EGFR T790M detection and osimertinib treatment response evaluation by liquid biopsy in lung adenocarcinoma patients with acquired resistance to first generation EGFR tyrosine kinase inhibitors

EGFR T790M detection and osimertinib treatment response evaluation by liquid biopsy in lung adenocarcinoma patients with acquired resistance to first generation EGFR tyrosine kinase inhibitors

Abstract Background Lung adenocarcinoma with EGFR activating mutations will inevitably acquire resistance to first generation TKIs. Acquired EGFR T790M mutation causes about 50% of these resistance cases. Droplet digital PCR (ddPCR) and cobas enables quantification of T790M mutation. Whether these m...

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Bibliographic Details
Main Authors: Chenguang Li, Rui Jia, Hailin Liu, Bin Zhang, Changli Wang
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Diagnostic Pathology
Subjects:
NSCLC
ctDNA
Epidermal growth factor receptor
T790M
Online Access:http://link.springer.com/article/10.1186/s13000-018-0728-6

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http://link.springer.com/article/10.1186/s13000-018-0728-6

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