Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy

Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy

The forkhead/winged helix transcription factor (Fox) p3 can regulate the expression of various genes, and it has been reported that the transfer of Foxp3-positive T cells could ameliorate cardiac hypertrophy and fibrosis. Triptolide (TP) can elevate the expression of Foxp3, but its effects on cardia...

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Bibliographic Details
Main Authors: Yuan-Yuan Ding, Jing-Mei Li, Feng-Jie Guo, Ya Liu, Yang-Fei Tong, Xi-Chun Pan, Xiao-Lan Lu, Wen Ye, Xiao-Hong Chen, Hai-Gang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Pharmacology
Subjects:
cardiac hypertrophy
cardiac fibrosis
Triptolide
Cardiac Injury
Forkhead box transcription factor p3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00471/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00471/full

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