Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator

Abstract Background Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a tissue plasminogen activator; tPA, has been advocated, but airway bleedin...

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Bibliographic Details
Main Authors: Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A. Cox, Marla R. Wolfson, Thomas H. Shaffer, Robert O. Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A. Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T. Ndetan, Karan P. Singh, Steven Idell
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Clinical and Translational Medicine
Subjects:
Plasminogen activators
Fibrinolysins
Plasminogen activator inhibitor-1
Inhalational acute lung injury
Online Access:http://link.springer.com/article/10.1186/s40169-018-0196-3

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http://link.springer.com/article/10.1186/s40169-018-0196-3

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