Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview

Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview

Proteasome emerged as an important target in recent pharmacological research due to its pivotal role in degrading proteins in the cytoplasm and nucleus of eukaryotic cells, regulating a wide variety of cellular pathways, including cell growth and proliferation, apoptosis, DNA repair, transcription,...

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Bibliographic Details
Main Authors: Romina A. Guedes, Patrícia Serra, Jorge A. R. Salvador, Rita C. Guedes
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Molecules
Subjects:
cancer
proteasome inhibitors
computer-aided drug design
virtual screening
molecular docking
pharmacophore model
Online Access:http://www.mdpi.com/1420-3049/21/7/927

Internet

http://www.mdpi.com/1420-3049/21/7/927

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