Role of Phospholipase D in G-Protein Coupled Receptor Function

Role of Phospholipase D in G-Protein Coupled Receptor Function

Prolonged agonist exposure of many G-protein coupled receptors induces a rapid receptor phosphorylation and uncoupling from G-proteins. Resensitization of these desensitized receptors requires endocytosis and subsequent dephosphorylation. Numerous studies show the involvement of phospholipid-specifi...

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Bibliographic Details
Main Authors: Lars-Ove Brandenburg, Thomas Pufe, Thomas Koch
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Membranes
Subjects:
phospholipase D
G-protein coupled receptor
internalization
endocytosis
desensitization
recycling
resensitization
Online Access:http://www.mdpi.com/2077-0375/4/3/302

Internet

http://www.mdpi.com/2077-0375/4/3/302

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