Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7

Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7

The chemokine receptor CCR7 plays a pivotal role in health and disease. In particular, CCR7 controls homing of antigen-bearing dendritic cells and T cells to lymph nodes, where adaptive immune responses are initiated. However, CCR7 also guides T cells to inflamed synovium and thereby contributes to...

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Bibliographic Details
Main Authors: Barbara D. Jakobs, Lisa Spannagel, Vladimir Purvanov, Edith Uetz-von Allmen, Christoph Matti, Daniel F. Legler
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
chemokine receptor
CCR7
chemokines
CCL19
nanobodies
β<sub>2</sub>-adrenergic receptor
bimolecular fluorescence complementation
split-luciferase complementation
Online Access:https://www.mdpi.com/1422-0067/20/10/2597

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https://www.mdpi.com/1422-0067/20/10/2597

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