Rational Drug Design of Axl Tyrosine Kinase Type I Inhibitors as Promising Candidates Against Cancer

The high level of Axl tyrosine kinase expression in various cancer cell lines makes it an attractive target for the development of anti-cancer drugs. In this study, we carried out several sets of in silico screening for the ATP-competitive Axl kinase inhibitors based on different molecular docking p...

Full description

Bibliographic Details
Main Authors: Edita Sarukhanyan, Sergey Shityakov, Thomas Dandekar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Chemistry
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00920/full