Natural Transmission of Helicobacter saguini Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10−/− Mice

Natural Transmission of Helicobacter saguini Causes Multigenerational Inflammatory Bowel Disease in C57/129 IL-10−/− Mice

While family history is a significant risk factor for developing inflammatory bowel disease (IBD), it is unclear whether the microbiome from parents is a transmissible influence on disease in their offspring. Furthermore, it is unknown whether IBD-associated microbes undergo genomic adaptations duri...

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Bibliographic Details
Main Authors: Anthony Mannion, Zeli Shen, Yan Feng, Dylan Puglisi, Sureshkumar Muthupalani, Mark T. Whary, James G. Fox
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mSphere
Subjects:
dna damage
helicobacter
cotton-top tamarins
germfree il-10−/− mice
inflammatory bowel disease
microbiome
microevolutions
multigenerational
whole-genome sequencing
Online Access:https://doi.org/10.1128/mSphere.00011-20

Internet

https://doi.org/10.1128/mSphere.00011-20

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