Design, Synthesis, and Biological Application of Novel Photoaffinity Probes of Dihydropyridine Derivatives, BAY R3401

Design, Synthesis, and Biological Application of Novel Photoaffinity Probes of Dihydropyridine Derivatives, BAY R3401

To explore the molecular mechanisms of BAY R3401, four types of novel photoaffinity probes bearing different secondary tags were synthesized. Their potency for glycogenolysis was evaluated in primary human liver HL-7702 cells and HepG2 cells. Probe 2d showed the best activity in primary human liver...

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Bibliographic Details
Main Authors: Liying Zhang, Zhiwei Yan, Youde Wang, Chengjun Song, Guangxin Miao
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
BAY R3401
molecular mechanism
type 2 diabetes
photoaffinity probe
glycogenolysis
photoaffinity labeling
target proteins
Online Access:https://www.mdpi.com/1420-3049/24/13/2394

Internet

https://www.mdpi.com/1420-3049/24/13/2394

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