Peptidoglycan Recognition Peptide 2 Aggravates Weight Loss in a Murine Model of Chemotherapy-Induced Gastrointestinal Toxicity

Peptidoglycan Recognition Peptide 2 Aggravates Weight Loss in a Murine Model of Chemotherapy-Induced Gastrointestinal Toxicity

Introduction: Chemotherapy-induced gastrointestinal toxicity (CIGT) is a frequent, severe and dose-limiting side effect. Few treatments have proven effective for CIGT. CIGT is characterized by activation of the nuclear factor kappa B pathway which, leads to upregulation of proinflammatory cytokines....

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Bibliographic Details
Main Authors: Ann-Sophie Bech, Anders Bathum Nexoe, Magdalena Dubik, Jesper Bonnet Moeller, Grith Lykke Soerensen, Uffe Holmskov, Gunvor Iben Madsen, Steffen Husby, Mathias Rathe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
peptidoglycan recognition peptide 2
gastrointestinal mucositis
mice
inflammation
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.635005/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.635005/full

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