Overexpression of CUGBP1 in skeletal muscle from adult classic myotonic dystrophy type 1 but not from myotonic dystrophy type 2.

Overexpression of CUGBP1 in skeletal muscle from adult classic myotonic dystrophy type 1 but not from myotonic dystrophy type 2.

Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are progressive multisystemic disorders caused by similar mutations at two different genetic loci. The common key feature of DM pathogenesis is nuclear accumulation of mutant RNA which causes aberrant alternative splicing of specific pre-mRNAs by alte...

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Bibliographic Details
Main Authors: Rosanna Cardani, Enrico Bugiardini, Laura V Renna, Giulia Rossi, Graziano Colombo, Rea Valaperta, Giuseppe Novelli, Annalisa Botta, Giovanni Meola
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3869793?pdf=render

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http://europepmc.org/articles/PMC3869793?pdf=render

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