Ezrin Enhances EGFR Signaling and Modulates Erlotinib Sensitivity in Non–Small Cell Lung Cancer Cells

Ezrin is a scaffolding protein that is involved in oncogenesis by linking cytoskeletal and membrane proteins. Ezrin interacts with epidermal growth factor receptor (EGFR) in the cell membrane, but little is known about the effects of this interaction on EGFR signaling pathway. In this study, we esta...

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Bibliographic Details
Main Authors: Yasemin Saygideğer-Kont, Tsion Zewdu Minas, Hayden Jones, Sarah Hour, Haydar Çelik, Idil Temel, Jenny Han, Nese Atabey, Hayriye Verda Erkizan, Jeffrey A. Toretsky, Aykut Üren
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558616000038