Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model.

Parkinson's disease (PD), characterized by loss of dopaminergic neurons in the substantia nigra, is a neurodegenerative disorder of central nervous system. The present study was designed to investigate the therapeutic effect of ACS84, a hydrogen sulfide-releasing-L-Dopa derivative compound, in...

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Bibliographic Details
Main Authors: Li Xie, Li-Fang Hu, Xing Qi Teo, Chi Xin Tiong, Valerio Tazzari, Anna Sparatore, Piero Del Soldato, Gavin Stewart Dawe, Jin-Song Bian
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3616069?pdf=render