By Regulating the NLRP3 Inflammasome Can Reduce the Release of Inflammatory Factors in the Co-Culture Model of Tuberculosis H37Ra Strain and Rat Microglia

By Regulating the NLRP3 Inflammasome Can Reduce the Release of Inflammatory Factors in the Co-Culture Model of Tuberculosis H37Ra Strain and Rat Microglia

ObjectiveTuberculosis infection of the Central Nervous System can cause severe inflammation in microglia, and NLRP3 inflammasome is also an important source of inflammation in microglia. Therefore, in this study, we used a co-culture model of rat microglia and tuberculosis H37Ra strain to explore th...

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Bibliographic Details
Main Authors: Zhen Xie, Hao Hui, Qian Yao, Yan Duan, Wu Li, Ye Cheng, Meng Zhang, Ye Tian, Gang Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
CNS tuberculosis infection
microglia
NLRP3 inflammasome
caspase-1
NF-κB
P2X7 receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.637769/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.637769/full

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