Dynamic Changes in Gene Mutational Landscape With Preservation of Core Mutations in Mantle Cell Lymphoma Cells

Dynamic Changes in Gene Mutational Landscape With Preservation of Core Mutations in Mantle Cell Lymphoma Cells

While studies have identified a number of mutations in mantle cell lymphoma (MCL), the list may still be incomplete and contribution to the pathogenesis remains unclear. We analyzed the mutational landscape of four mantle cell lymphoma biopsies obtained during an 8-year period from the same patient...

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Bibliographic Details
Main Authors: Qian Zhang, Hong Y. Wang, Xiaobin Liu, Michael H. Roth, Alex A. Shestov, Seung-Cheol Lee, Kanika Jain, Craig Soderquist, Qun-Bin Xiong, Marco Ruella, Honore Strauser, Jerry D. Glickson, Stephen J. Schuster, Andrzej Ptasznik, Mariusz A. Wasik
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Oncology
Subjects:
mantle cell lymphoma
Bruton's tyrosine kinase
histone 3/lysine 4 (H3K4) demethylase
ibrutinib
KDM5C
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00568/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00568/full

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