The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity

The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity

Abstract Background The IκB kinase (IKK) complex, comprising the two enzymes IKKα and IKKβ, is the main activator of the inflammatory transcription factor NF-κB, which is constitutively active in many cancers. While several connections between NF-κB signaling and the oncogene c-Myc have been shown,...

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Bibliographic Details
Main Authors: Bernhard Moser, Bernhard Hochreiter, José Basílio, Viola Gleitsmann, Anja Panhuber, Alan Pardo-Garcia, Bastian Hoesel, Manuel Salzmann, Ulrike Resch, Mamoona Noreen, Johannes A. Schmid
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Cancer
Subjects:
c-Myc
IKKα
NF-κB
Cancer
Inflammation
Online Access:https://doi.org/10.1186/s12943-021-01308-8

Internet

https://doi.org/10.1186/s12943-021-01308-8

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