The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity
The prevention of type 2 diabetes involves a healthy diet rich in triterpenes. The aim of this study was to evaluate the influence of a natural triterpene preparation (ursolic acid and oleanolic acid) obtained from apple peels (AP) on the morphology of selected gastrointestinal tract tissues in gilt...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2017-06-01
|
Series: | Journal of Functional Foods |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617301366 |
id |
doaj-94af255f3b5f48dcb0af83218b769ea0 |
---|---|
record_format |
Article |
spelling |
doaj-94af255f3b5f48dcb0af83218b769ea02021-04-30T07:09:56ZengElsevierJournal of Functional Foods1756-46462017-06-01331120The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activityMagdalena Gajęcka0Barbara Przybylska-Gornowicz1Małgorzata Zakłos-Szyda2Michał Dąbrowski3Lech Michalczuk4Maria Koziołkiewicz5Andrzej Babuchowski6Łukasz Zielonka7Bogdan Lewczuk8Maciej Tadeusz Gajęcki9Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, Poland; Department of Epizootiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/9, 10-718 Olsztyn, PolandDepartment of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, PolandInstitute of Technical Biochemistry, Faculty of Biotechnology and Food Science, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Łódź, PolandDepartment of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, PolandDepartment of General Biology, Research Institute of Horticulture, Pomologiczna 18, 96-100 Skierniewice, Poland; Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Wólczańska 171/173, 90-924 Łódź, PolandInstitute of Technical Biochemistry, Faculty of Biotechnology and Food Science, Lodz University of Technology, Stefanowskiego 4/10, 90-924 Łódź, PolandDairy Industry Innovation Institute Ltd., Kormoranów 1, 11-700 Mrągowo, PolandDepartment of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, Poland; Corresponding author.Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10-718 Olsztyn, PolandDepartment of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, PolandThe prevention of type 2 diabetes involves a healthy diet rich in triterpenes. The aim of this study was to evaluate the influence of a natural triterpene preparation (ursolic acid and oleanolic acid) obtained from apple peels (AP) on the morphology of selected gastrointestinal tract tissues in gilts with streptozotocin (STZ)-induced diabetes, and on glucose and lipid metabolism in various cells analyzed in vitro. Subclinical enteropathy with a constant degree of severity was observed in the jejunum in vivo. The AP preparation exerted protective effects in the liver and pancreas of gilts with diabetes. The data obtained in vitro indicate that the AP preparation had anti-diabetic and anti-obesity effects. The preparation also stimulated glucose uptake by myoblasts, hepatocytes and adipocytes. The results of in vivo and in vitro experiments indicate that the analyzed preparation exerted hypoglycemic effects on the liver and pancreas, and induced subclinical enteropathy in the jejunum.http://www.sciencedirect.com/science/article/pii/S1756464617301366TriterpenesDiabetesStreptozotocinGastrointestinal histologyCell culturesGilts |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Magdalena Gajęcka Barbara Przybylska-Gornowicz Małgorzata Zakłos-Szyda Michał Dąbrowski Lech Michalczuk Maria Koziołkiewicz Andrzej Babuchowski Łukasz Zielonka Bogdan Lewczuk Maciej Tadeusz Gajęcki |
spellingShingle |
Magdalena Gajęcka Barbara Przybylska-Gornowicz Małgorzata Zakłos-Szyda Michał Dąbrowski Lech Michalczuk Maria Koziołkiewicz Andrzej Babuchowski Łukasz Zielonka Bogdan Lewczuk Maciej Tadeusz Gajęcki The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity Journal of Functional Foods Triterpenes Diabetes Streptozotocin Gastrointestinal histology Cell cultures Gilts |
author_facet |
Magdalena Gajęcka Barbara Przybylska-Gornowicz Małgorzata Zakłos-Szyda Michał Dąbrowski Lech Michalczuk Maria Koziołkiewicz Andrzej Babuchowski Łukasz Zielonka Bogdan Lewczuk Maciej Tadeusz Gajęcki |
author_sort |
Magdalena Gajęcka |
title |
The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity |
title_short |
The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity |
title_full |
The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity |
title_fullStr |
The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity |
title_full_unstemmed |
The influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity |
title_sort |
influence of a natural triterpene preparation on the gastrointestinal tract of gilts with streptozocin-induced diabetes and on cell metabolic activity |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2017-06-01 |
description |
The prevention of type 2 diabetes involves a healthy diet rich in triterpenes. The aim of this study was to evaluate the influence of a natural triterpene preparation (ursolic acid and oleanolic acid) obtained from apple peels (AP) on the morphology of selected gastrointestinal tract tissues in gilts with streptozotocin (STZ)-induced diabetes, and on glucose and lipid metabolism in various cells analyzed in vitro. Subclinical enteropathy with a constant degree of severity was observed in the jejunum in vivo. The AP preparation exerted protective effects in the liver and pancreas of gilts with diabetes. The data obtained in vitro indicate that the AP preparation had anti-diabetic and anti-obesity effects. The preparation also stimulated glucose uptake by myoblasts, hepatocytes and adipocytes. The results of in vivo and in vitro experiments indicate that the analyzed preparation exerted hypoglycemic effects on the liver and pancreas, and induced subclinical enteropathy in the jejunum. |
topic |
Triterpenes Diabetes Streptozotocin Gastrointestinal histology Cell cultures Gilts |
url |
http://www.sciencedirect.com/science/article/pii/S1756464617301366 |
work_keys_str_mv |
AT magdalenagajecka theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT barbaraprzybylskagornowicz theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT małgorzatazakłosszyda theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT michałdabrowski theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT lechmichalczuk theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT mariakoziołkiewicz theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT andrzejbabuchowski theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT łukaszzielonka theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT bogdanlewczuk theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT maciejtadeuszgajecki theinfluenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT magdalenagajecka influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT barbaraprzybylskagornowicz influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT małgorzatazakłosszyda influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT michałdabrowski influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT lechmichalczuk influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT mariakoziołkiewicz influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT andrzejbabuchowski influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT łukaszzielonka influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT bogdanlewczuk influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity AT maciejtadeuszgajecki influenceofanaturaltriterpenepreparationonthegastrointestinaltractofgiltswithstreptozocininduceddiabetesandoncellmetabolicactivity |
_version_ |
1721499546309099520 |