Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor

Activation of Shc1 Allows Oncostatin M to Induce RANKL and Osteoclast Formation More Effectively Than Leukemia Inhibitory Factor

Background and Purpose: The gp130 family of cytokines signals through receptors dimerizing with the gp130 subunit. Downstream signaling typically activates STAT3 but also SHP2/Ras/MAPK pathways. Oncostatin M (OSM) is a unique cytokine in this family since the receptor (OSMR) activates a non-redundan...

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Bibliographic Details
Main Authors: Emma Persson, Pedro P. C. Souza, Thais Floriano-Marcelino, Howard Herschel Conaway, Petra Henning, Ulf H. Lerner
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
OSM
LIF
RANKL
Shc1
osteoclast
bone resorption
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01164/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01164/full

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