Identification and Evaluation of Inhibitors of Lipase from <i>Malassezia restricta</i> using Virtual High-Throughput Screening and Molecular Dynamics Studies

Identification and Evaluation of Inhibitors of Lipase from <i>Malassezia restricta</i> using Virtual High-Throughput Screening and Molecular Dynamics Studies

Recent studies revealed the role of lipase in the pathogenicity of <i>Malassezia restricta</i> in dandruff and seborrheic dermatitis (D/SD). The lipase from <i>M. restricta</i> (Mrlip1) is considered a potential target for dandruff therapy. In this work, we performed structur...

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Bibliographic Details
Main Authors: Shahid Ali, Faez Iqbal Khan, Taj Mohammad, Dongming Lan, Md. Imtaiyaz Hassan, Yonghua Wang
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
traditional Chinese medicine
lipase
<i>Malassezia restricta</i>
molecular dynamics simulation
anti-dandruff
Zinc database
drug design and discovery
Online Access:https://www.mdpi.com/1422-0067/20/4/884

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https://www.mdpi.com/1422-0067/20/4/884

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