Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

“Variation in the noncoding regulatory sequences in the genome plays important roles in human disease and evolution. Here, the authors use F1 mouse hybrids to shed light on the regulatory mechanisms mediating transcription factor binding, chromatin state and gene expression in mammalian cells.”

Bibliographic Details
Main Authors: Emily S. Wong, Bianca M. Schmitt, Anastasiya Kazachenka, David Thybert, Aisling Redmond, Frances Connor, Tim F. Rayner, Christine Feig, Anne C. Ferguson-Smith, John C. Marioni, Duncan T. Odom, Paul Flicek
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01037-x

Internet

https://doi.org/10.1038/s41467-017-01037-x

Similar Items