Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

Insulin receptor substrate-2-deficient (IRS2−/−) mice are considered a good model to study the development of diabetes because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis and cell survival. The hypothalamus might play a...

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Bibliographic Details
Main Authors: Eva Baquedano, Emma Burgos-Ramos, Sandra Canelles, Agueda González-Rodríguez, Julie A. Chowen, Jesús Argente, Vicente Barrios, Angela M. Valverde, Laura M. Frago
Format: Article
Language:English
Published: The Company of Biologists 2016-05-01
Series:Disease Models & Mechanisms
Subjects:
Diabetes
Cell death
IRS2
Apoptosis
Oxidative stress
Hypothalamus
Online Access:http://dmm.biologists.org/content/9/5/573

Internet

http://dmm.biologists.org/content/9/5/573

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