Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway.

Synergistic apoptosis of CML cells by buthionine sulfoximine and hydroxychavicol correlates with activation of AIF and GSH-ROS-JNK-ERK-iNOS pathway.

BACKGROUND: Hydroxychavicol (HCH), a constituent of Piper betle leaf has been reported to exert anti-leukemic activity through induction of reactive oxygen species (ROS). The aim of the study is to optimize the oxidative stress -induced chronic myeloid leukemic (CML) cell death by combining glutathi...

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Bibliographic Details
Main Authors: Avik Acharya Chowdhury, Jaydeep Chaudhuri, Nabendu Biswas, Anirban Manna, Saurav Chatterjee, Sanjit K Mahato, Utpal Chaudhuri, Parasuraman Jaisankar, Santu Bandyopadhyay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3767640?pdf=render

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http://europepmc.org/articles/PMC3767640?pdf=render

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