5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze.

5-HTT deficiency affects neuroplasticity and increases stress sensitivity resulting in altered spatial learning performance in the Morris water maze but not in the Barnes maze.

The purpose of this study was to evaluate whether spatial hippocampus-dependent learning is affected by the serotonergic system and stress. Therefore, 5-HTT knockout (-/-), heterozygous (+/-) and wildtype (+/+) mice were subjected to the Barnes maze (BM) and the Morris water maze (WM), the latter be...

Full description

Bibliographic Details
Main Authors: Margherita M Karabeg, Sandra Grauthoff, Sina Y Kollert, Magdalena Weidner, Rebecca S Heiming, Friederike Jansen, Sandy Popp, Sylvia Kaiser, Klaus-Peter Lesch, Norbert Sachser, Angelika G Schmitt, Lars Lewejohann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3805519?pdf=render

Internet

http://europepmc.org/articles/PMC3805519?pdf=render

Similar Items