Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains

Partial Mechanical Unloading of the Heart Disrupts L-Type Calcium Channel and Beta-Adrenoceptor Signaling Microdomains

Introduction: We investigated the effect of partial mechanical unloading (PMU) of the heart on the physiology of calcium and beta-adrenoceptor-cAMP (βAR-cAMP) microdomains. Previous studies have investigated PMU using a model of heterotopic-heart and lung transplantation (HTHAL). These studies have...

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Bibliographic Details
Main Authors: Peter T. Wright, Jose L. Sanchez-Alonso, Carla Lucarelli, Anita Alvarez-Laviada, Claire E. Poulet, Sean O. Bello, Giuseppe Faggian, Cesare M. Terracciano, Julia Gorelik
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Physiology
Subjects:
cAMP
beta-adrenergic
excitation-contraction
calcium
microdomains
cardiac
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01302/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01302/full

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