Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer

Computational Insight Into the Structural Organization of Full-Length Toll-Like Receptor 4 Dimer in a Model Phospholipid Bilayer

Toll-like receptors (TLRs) are a unique category of pattern recognition receptors that recognize distinct pathogenic components, often utilizing the same set of downstream adaptors. Specific molecular features of extracellular, transmembrane (TM), and cytoplasmic domains of TLRs are crucial for coor...

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Bibliographic Details
Main Authors: Mahesh Chandra Patra, Hyuk-Kwon Kwon, Maria Batool, Sangdun Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
full-length TLR
TLR4
plasma membrane
molecular dynamics simulation
signal transduction
adaptor recruitment
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00489/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00489/full

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