Group A streptococcal antigen exposed rat model to investigate neurobehavioral and cardiac complications associated with post‐streptococcal autoimmune sequelae

Group A streptococcal antigen exposed rat model to investigate neurobehavioral and cardiac complications associated with post‐streptococcal autoimmune sequelae

Abstract Background The neuropsychiatric disorders due to post‐streptococcal autoimmune complications such as Sydenham's chorea (SC) are associated with acute rheumatic fever and rheumatic heart disease (ARF/RHD). An animal model that exhibits characteristics of both cardiac and neurobehavioral...

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Bibliographic Details
Main Authors: Rukshan A. M. Rafeek, Catherine M. Lobbe, Ethan C. Wilkinson, Adam S. Hamlin, Nicholas M. Andronicos, David J. McMillan, Kadaba S. Sriprakash, Natkunam Ketheesan
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Animal Models and Experimental Medicine
Subjects:
animal model
group A streptococcus
Lewis rats
paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)
rheumatic fever
rheumatic heart disease
Online Access:https://doi.org/10.1002/ame2.12164

Internet

https://doi.org/10.1002/ame2.12164

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