Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice

Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice

Aims/Hypothesis: Galectin 3 appears to play a proinflammatory role in several inflammatory and autoimmune diseases. Also, there is evidence that galectin 3 plays a role in both type-1 and type-2 diabetes. During obesity, hematopoietic cell-derived galectin 3 induces insulin resistance. While the rol...

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Bibliographic Details
Main Authors: Ivica Petrovic, Nada Pejnovic, Biljana Ljujic, Sladjana Pavlovic, Marina Miletic Kovacevic, Ilija Jeftic, Aleksandar Djukic, Nevena Draginic, Marijana Andjic, Nebojsa Arsenijevic, Miodrag L. Lukic, Nemanja Jovicic
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Endocrinology
Subjects:
galectin 3
type-2 diabetes
β cells
apoptosis
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00030/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2020.00030/full

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