Small RNA Sequencing Identifies PIWI-Interacting RNAs Deregulated in Glioblastoma—piR-9491 and piR-12488 Reduce Tumor Cell Colonies In Vitro

Small RNA Sequencing Identifies PIWI-Interacting RNAs Deregulated in Glioblastoma—piR-9491 and piR-12488 Reduce Tumor Cell Colonies In Vitro

Glioblastoma (GBM) is the most frequently occurring primary malignant brain tumor of astrocytic origin. To change poor prognosis, it is necessary to deeply understand the molecular mechanisms of gliomagenesis and identify new potential biomarkers and therapeutic targets. PIWI-interacting RNAs (piRNA...

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Bibliographic Details
Main Authors: Michael Bartos, Frantisek Siegl, Alena Kopkova, Lenka Radova, Jan Oppelt, Marek Vecera, Tomas Kazda, Radim Jancalek, Michal Hendrych, Marketa Hermanova, Petra Kasparova, Zuzana Pleskacova, Vaclav Vybihal, Pavel Fadrus, Martin Smrcka, Radek Lakomy, Radim Lipina, Tomas Cesak, Ondrej Slaby, Jiri Sana
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
PIWI-interacting RNA
piRNA
diagnosis
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.707017/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.707017/full

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