Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production

Terpenoids are natural products known for their medicinal and commercial applications. Metabolic engineering of microbial hosts for the production of valuable compounds, such as artemisinin and Taxol, has gained vast interest in the last few decades. The Generally Regarded As Safe (GRAS) Bacillus su...

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Bibliographic Details
Main Authors: Ingy I. Abdallah, Hegar Pramastya, Ronald van Merkerk, Sukrasno, Wim J. Quax
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
MEP
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00218/full