Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones

Convenient Synthesis of Thiohydantoins, Imidazole-2-thiones and Imidazo[2,1-b]thiazol-4-iums from Polymer-Supported α-Acylamino Ketones

The preparation of 5-methylene-thiohydantoins using solid-phase synthesis is reported in this paper. After sulfonylation of immobilized Ser (t-Bu)-OH with 4-nitrobenzenesulfonyl chloride followed by alkylation with various bromoketones, the 4-Nos group was removed and the resulting polymer-supported...

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Bibliographic Details
Main Authors: Petra Králová, Michal Maloň, Hiroyuki Koshino, Miroslav Soural
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Molecules
Subjects:
heterocycle
thiohydantoin
imidazole
serine
bromoketone
solid-phase synthesis
Online Access:http://www.mdpi.com/1420-3049/23/4/976

Internet

http://www.mdpi.com/1420-3049/23/4/976

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