A Strategy for Combinatorial Cavity Design in De Novo Proteins

Protein sequence space is vast; nature uses only an infinitesimal fraction of possible sequences to sustain life. Are there solutions to biological problems other than those provided by nature? Can we create artificial proteins that sustain life? To investigate these questions, we have created combi...

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Bibliographic Details
Main Authors: Christina Karas, Michael Hecht
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/10/2/9