A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides

A GH89 human α-N-acetylglucosaminidase (hNAGLU) homologue from gut microbe Bacteroides thetaiotaomicron capable of hydrolyzing heparosan oligosaccharides

Abstract Carbohydrate-Active enZYme (CAZY) GH89 family enzymes catalyze the cleavage of terminal α-N-acetylglucosamine from glycans and glycoconjugates. Although structurally and mechanistically similar to the human lysosomal α-N-acetylglucosaminidase (hNAGLU) in GH89 which is involved in the degrad...

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Bibliographic Details
Main Authors: Xiaohong Yang, Xiaoxiao Yang, Hai Yu, Lan Na, Tamashree Ghosh, John B. McArthur, Tsui-Fen Chou, Patricia Dickson, Xi Chen
Format: Article
Language:English
Published: SpringerOpen 2021-06-01
Series:AMB Express
Subjects:
α-N-Acetylglucosaminidase
NAGLU
Bacterial glycoside hydrolases
Heparosan oligosaccharides
Bacteroides thetaiotaomicron
Online Access:https://doi.org/10.1186/s13568-021-01253-1

Internet

https://doi.org/10.1186/s13568-021-01253-1

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