BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells

BRCA2 Deletion Induces Alternative Lengthening of Telomeres in Telomerase Positive Colon Cancer Cells

BRCA1/2 are tumor suppressor genes controlling genomic stability also at telomeric and subtelomeric loci. Their mutation confers a predisposition to different human cancers but also sensitivity to antitumor drugs including poly(ADP-ribose) polymerase (PARP) inhibitors and G-quadruplex stabilizers. H...

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Bibliographic Details
Main Authors: Luca Pompili, Carmen Maresca, Angela Dello Stritto, Annamaria Biroccio, Erica Salvati
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Genes
Subjects:
BRCA2 mutation
telomeres
ALT
Online Access:https://www.mdpi.com/2073-4425/10/9/697

Internet

https://www.mdpi.com/2073-4425/10/9/697

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